Crestor

A member of the drug class of statins, Rosuvastatin is used to treat high cholesterol and connected conditions, plus to prevent cardiovascular disease. It is developed by Shionogi and is marketed by the pharmaceutical company AstraZeneca. In India, the medication is marketed as Rozavel by Sun pharma and in Pakistan it is manufactured and marketed as "Rolip" by Hilton pharma.

Medications and Prescriptions
Generic name: rosuvastatin

Product Brand Name: Rosuvastatin generic


Crestor description
Known in USA as Crestor, Rosuvastatin is available in tablet form (10, 20 mg) for oral administration.
Mechanism of action:

A competitive inhibitor of the enzyme HMG-CoA reductase, Rosuvastatin has a mechanism of action like other statins. Its estimated elimination half life is 19 hours and its time to peak plasma concentration is reached in 3–5 hours following oral administration.

Indications and regulation:

Rosuvastatin is approved for the treatment of total cholesterol (hypercholesterolemia), high LDL cholesterol (dyslipidemia), and/or triglycerides (hypertriglyceridemia).
As of 2004, rosuvastatin had been launched in 56 and approved in 154 countries. On August 12, 2003, approval in the United States by the FDA came.

In 2008, research emerged that rosuvastatin could decrease the possibility of heart attack, stroke, and other vascular complications in patients with elevated C-reactive protein but no other risk factors.[5] This could powerfully impact medical practice by placing various patients on statin prophylaxis that or else would have been untreated.

The results of the JUPITER trial suggested that rosuvastatin may decrease the comparative possibility of heart attack and stroke in patients without hyperlipidemia.
The AURORA trial randomized 2776 patients undergoing hemodialysis to receive either rosuvastatin or placebo. The randomized, double-blind study found no difference in the two groups in the primary end point, a combination of cardiovascular mortality, nonfatal myocardial infarction, or nonfatal stroke. The study found no difference in all-cause mortality among this population at a mean follow up of 3.8 years.

Effects on cholesterol levels:

The effects of rosuvastatin on LDL cholesterol are dose-related. In one trial, the average LDL cholesterol reduction was found to be 46% at the 10 mg dose. Increasing the dose from 10 mg to 40 mg gave a diffident raise of an extra 9% absolute reduction in LDL levels (55% below baseline levels).



Crestor notes:
A member of class statins, Crestor - generic name rosuvastatin - is used to treat high cholesterol and to prevent cardiovascular disease. It works by reducing levels of low density lipoprotein cholesterol and triglycerides in the blood whereas increasing levels of high density lipoprotein (HDL).
Lowering cholesterol can help prevent heart disease and hardening of arteries that can lead to heart attack, stroke and vascular disease. Approved as a treatment for hypercholesterolemia, Rosuvastatin calcium is a synthetic lipid lowering agent. It is a part of total program that also includes diet, exercise and weight control. Crestor side effects includes tenderness, muscle pain, urinating more or less than usual, clay-colored stools, loss of appetite, chest pain, sore throat, mild nausea, runny or stuffy nose, headache or memory loss.
Keep away from drinking alcohol while taking crestor as it can increase triglyceride levels. It is suggested not to take this drug if allergic to rosuvastatin, have liver disease or if you are pregnant or breast feeding a baby. Stock up this medication at room temperature away from moisture and heat.