Aredia

Aridia medicine, a bone loss inhibitor, is used to treat high calcium levels or softening of the bone caused by certain cancers. The drug may also be used to treat Paget's disease and other conditions as determined by your doctor.


Medications and Prescriptions
Generic name: Pamindronate

Product Brand Name: Pamitor

Product Manufacturer: Torrex
Aredia description
It is necessary that you should inform INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking, before you start using this medicine: if you are taking chemotherapy or corticosteroids, ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed. Also report the use of other medicines which might be potentially toxic to the kidney such as aminoglycosides (e.g., gentamicin, amikacin), amphotericin d B, cyclosporine, non-steroidal anti-iou snflammatory medicines (e.g., ibuprofen), tacrolimus, or vancomycin. If you develop any other medical conditions such as kidney disease, cancer, dental problems, bone infection, allergies, pregnancy, or breast-feeding, inform your doctor. Contact your doctor or pharmacist if you have any questions or u about taking this medicine.

Hypercalcemia of Malignancy:
Aredia, combined with adequate hydration, is used for the treatment of moderate or severe hypercalcemia associated with tumor, with or without bone metastases. Patients who have either epidermoid or non-epidermoid tumors respond to treatment with Aredia. Vigorous saline hydration, an integral part of hypercalcemia therapy, should be initiated promptly and an attempt should be made to restore the urine output to about 2 L/day throughout treatment. Mild or asymptomatic hypercalcemia may be treated with conservative measures (i.e., saline hydration, with or without loop diuretics). Hydration should be done adequately for the patients throughout the treatment. However, overhydration, particularly in those patients who have cardiac failure, must be avoided. An important point is that Diuretic therapy should not be employed before the correction of hypovolemia. The safety and efficiency of Aredia in the treatment of hypercalcemia associated with hyperparathyroidism or with other non-tumor-related conditions has not been determined.

Paget's disease:

The medicine recommended for the treatment of patients with Paget's disease of bone is Aredia whose effectiveness was demonstrated primarily in patients with serum alkaline phosphatase ЎЭ 3 times the upper limit of normal. Aredia helps in reducing serum alkaline phosphatase and urinary hydroxyproline lev els by ЎЭ 50% in at least 50% of patients, and by ЎЭ 30% in at least 80% of patients with Paget's disease. Aredia therapy has also been effective in reducing these biochemical markers in patients with Paget's disease who failed to respond, or no longer responded to other treatments.
Osteolytic Bone Metastases of Breast Cancer and Osteolytic Lesions of Multiple Myeloma:
Combined with standard antineoplastic therapy, Aredia is suggested for for the treatment of osteolytic bone metastases of breast cancer and osteolytic lesions of multiple myeloma. Though the Aredia treatment effect appeared to be smaller in the study of breast cancer patients receiving hormonal therapy than in the study of those receiving chemotherapy, the overall confirmation of clinical benefit has been proven.

How to Use This Medicine:
You are supposed to follow the directions for using this medicine provided by your doctor. Usually administered as an infusion at a hospital or clinic, Aredia is sometimes used at home as an injection. If you are using this medicine at home, stick on to the detailed instructions provided by your doctor. Ask any questions that you may have about this medicine or giving injections. Aredia is to be stored as directed on the prescription label.
Cautions:
While you are using this medicine, try to keep ALL DOCTOR AND LABORATORY APPOINTMENTS (e.g. kidney function tests). Ensure that you do NOT EXCEED THE RECOMMENDED DOSE without checking with your doctor. THIS MEDICINE MAY CAUSE JAWBONE PROBLEMS in some patients, especially those who have cancer, are using certain medicines (such as chemotherapy or corticosteroids), or who have poor dental hygiene. These problems have been often associated with dental procedures. An appropriate dental examination is to be discussed with your doctor before you begin treatment with this medicine because it is required to avoid certain dental procedures while you are using this medicine. Ask your doctor any questions you may have about dental treatments while you are using this medicine. It is also necessary to maintain good nutrition habits WHILE TAKING THIS MEDICINE. Be sure to ask your doctor or pharmacist about taking a calcium and vitamin D supplement. FOR WOMEN: As Aredia HAS BEEN SHOWN TO CAUSE HARM to the human fetus, pregnant women are required to discuss the benefits and risks of using this medicine during pregnancy. There is no idea if this MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
Possible Side Effects:
Some of the side effects that may be experienced are nausea, constipation, or a mild fever for 24-48 hours. Though the side effects may recede during treatment, check with your doctor if they continue. Also, CHECK WITH YOUR DOCTOR immediately if you experience pain, swelling or redness at injection site, continued bone pain, jaw pain or swelling, persistent fever, loss of appetite, vomiting, confusion, weakness, fatigue, or muscle cramps. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Overdose:
Contact your local poison control center or emergency room immediately, if overdose is suspected.
Additional Information:
This medicine is not to be shared with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions and KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children. Ensure not to reuse needles, syringes, or other materials and dispose properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full.


How Supplied:
Vials - 30 mg - each contains 30 mg of sterile, lyophilized pamidronate disodium and 470 mg of mannitol, USP.

Vials - 90 mg - each contains 90 mg of sterile, lyophilized pamidronate disodium and 375 mg of mannitol, USP.

It should not be stored above 30ЎгC (86ЎгF).

Items of interest:
pamindronate, pamitor, torrex, bone loss inhibitor, aridia, aredia infusion, aredia medication, aredia drug, aredia prescription information, aredium, aredia osteoporosis.


Aredia notes:
Also known by the product names pamindronate, Pamitor and Torrex Aredia medication, Aredia is a bone loss inhibitor that is utilized in treating high calcium levels and softening of the bone as a result of certain types of cancers. Apart from using it for the treatment of Paget's disease, you can also treat Aredia osteoporosis and other disorders.

Inform your doctor before using this medicine and never forget to take a note of the Aredia prescription information before taking the dose of aredia drug. You may also need further monitoring of your condition or dose by people who are under chemotherapy or corticosteroid treatment. It is necessary to avoid taking medicines that are potentially toxic to the kidney like aminoglycosides such as cyclosporine, tacrolimus, vancomycin, amphotericin B, gentamicin and amikacin, and non-steroidal anti-inflammatory medicine like ibuprofen. Patients who are affected by cancer, kidney disease, bone infection, dental problems, allergies and pregnant and nursing mothers should avoid Aredia. You will need the help of doctor and laboratory appointments while using this medicine.

It is strongly recommended not to exceed the recommended dose of this drug without consulting your doctor. You can possibly experience jawbone problems, especially by people who are suffering from cancer and going on with certain medicines or having a poor dental hygiene. Consult your doctor about suitable dental examination before beginning treatment with Aredia and try to avoid certain dental procedures while using this drug. A dose of 90 mg Aredia infusion has to be administered over 4 hours. It is to be noted that pregnant women or those who are expecting pregnancy should consult their doctor. Mild fever, nausea, constipation, muscle cramps, loss of appetite and jaw pain are some of the side effects of Aredium.